What is a common term for the transition of small lymphocytic lymphoma (SLL) to chronic lymphocytic leukemia (CLL)?

The transition of small lymphocytic lymphoma (SLL) to chronic lymphocytic leukemia (CLL) is commonly referred to as leukemic transformation. This term accurately describes the process by which a previously indolent lymphoma transforms into a more aggressive form of leukemia.

SLL and CLL are considered different manifestations of the same disease, primarily differentiated by the extent of lymphocytosis (an increased number of lymphocytes in the blood). In SLL, the disease is typically more localized and presents primarily in lymph nodes, while CLL involves an increased lymphocyte count in the peripheral blood and often has a more systemic impact. When SLL progresses to CLL, it signifies an escalation in disease severity and can result in different treatment approaches.

The other terms provided do not capture this specific process. A secondary malignancy refers to a completely different cancer developing as a result of prior malignancy or treatment, which does not relate to SLL or CLL transitioning. Progressive disease indicates a worsening of disease but does not specifically denote the transformation from SLL to CLL. Remission signifies a period where the disease is reduced or undetectable, and thus is not applicable to the concept of transformation.